Superoxide dismutase (SOD)-catalase conjugates. Role of hydrogen peroxide and the Fenton reaction in SOD toxicity.
نویسندگان
چکیده
منابع مشابه
Superoxide dismutase (SOD) catalyses the conversion of the superoxide radical to hydrogen peroxide and oxygen (McCord
oxygen species that are known to induce the peroxidation of polyunsaturated lipids in cell membranes and to cause degradation of structural proteins, enzymes and ribonucleic acids. These reactive intermediates of oxygen metabolism are converted mainly into molecular oxygen and water by antioxidant enzymes and normally are kept to a minimum in blood and organ tissues (Fridovich, 1978; Fridovich ...
متن کاملThe metalloenzyme superoxide dismutase (SOD) catalyses the conversion of superoxide radical anion to oxygen and hydrogen peroxide (McCord
Molecular Infectious Diseases Groupf Department of Paediatrics, Imperial College of Science, Technology and Medicine, S t Mary's Hospital, London Copperand zinc-containing superoxide dismutases ([Cu,Zn]-SODS) are generally considered almost exclusively eukaryotic enzymes, protecting the cytosol and extracellular compartments of higher organisms from damage by oxygen free-radicals. The recent de...
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Superoxide dismutase (SOD)-deficient Escherichia coli OX326A cells are protected against chemically-induced oxidative stress by expression of the chaperonin GroESL. This protection is equivalent to expression of superoxide dismutase even though GroESL has no inherent SOD activity. Co-overexpression of GroESL and SOD in the same cells results in higher protein yields of SOD and greater metallati...
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The use of chemical advances to mechanical research, improvement, and assembling has turned into a critical field. Since the creation of rough rennet in 1874, a few catalysts have been marketed, and utilized for restorative, supplementary, and different applications. Late headways in biotechnology now enable organizations to create more secure and more affordable chemicals with upgraded intensi...
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Extracellular superoxide dismutase (EC-SOD) is a metalloprotein and functions as an antioxidant enzyme. In this study, we used lentiviral vectors to generate transgenic chickens that express the human EC-SOD gene. The recombinant lentiviruses were injected into the subgerminal cavity of freshly laid eggs. Subsequently, the embryos were incubated to hatch using phases II and III of the surrogate...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)54167-3